VEZOTIL

VEZOTILInnovativeAnesthesia

Safe and effective veterinary anesthetic with precise dosing. Tiletamine + Zolazepam for professional veterinary practice.

Safety First
Proven formula
Rapid Action
Effect in minutes
STATUS: READY

DRUG ANALYSIS

Tiletamine:50 mg/ml
Zolazepam:50 mg/ml
Volume:5 ml
Efficacy:98.7%
DOSAGE: CALCULATED

About VEZOTIL

An innovative veterinary lyophilisate for injection solution preparation. Developed by VETSTEM LLC for safe and effective animal anesthesia.
Registration No. 77-3-29.23-5075ПВР-3-29.23/03889 dated 12.04.2024

Drug Composition

Tiletamine hydrochloride250 mg
Zolazepam hydrochloride250 mg
Dosage formLyophilisate
Vial volume5 ml

Mechanism of Action

Tiletamine provides dissociative anesthesia by blocking NMDA receptors. Zolazepam enhances GABA activity, providing sedation and muscle relaxation.

The combination ensures balanced anesthesia with minimal side effects on respiratory and cardiovascular systems.

VEZOTIL Advantages

A modern approach to veterinary anesthesia with proven efficacy and safety

MONITORING ACTIVE
PARAMETERS NORMAL
ANESTHESIA CONTROL
SAFE APPLICATION

High Safety

Minimal impact on vital body functions

98.5% successful procedures

Rapid Action

Anesthesia onset in 3-5 minutes after administration

3-5 min to effect

Stable Parameters

Maintains stable hemodynamics during procedures

HR and BP normal

Wide Application Range

Suitable for various animal species and procedures

15+ animal species

Controlled Anesthesia

Predictable duration and recovery time

30-90 min duration

GMP Quality

Manufactured according to international standards

GMP certified

Clinical Performance

98.5%
Successful Operations
<3min
Induction Time
60min
Average Duration
15+
Animal Species

Indications for Use

VEZOTIL is suitable for a wide range of veterinary procedures

Animal Species

Dogs

All breeds and sizes

Cats

Domestic and wild

Exotic

Reptiles, birds

Types of Procedures

Surgical Operations

Elective and emergency surgical interventions

Neutering/Spaying
Tumor removal
Orthopedic surgery

Diagnostic Procedures

Examinations requiring animal immobility

X-ray imaging
CT and MRI
Endoscopy

Painful Manipulations

Procedures causing discomfort to animals

Tissue biopsy
Drainage
Wound treatment

Recommended Dosages

Dogs
0.2-0.4 ml/kg
depending on size
Cats
0.15-0.3 ml/kg
individually adjusted
Exotic
0.1-0.5 ml/kg
as recommended by veterinarian

Application Guide

Step-by-step guide for safe use of VEZOTIL

01

Solution Preparation

Reconstitute lyophilisate with sterile water for injection

Add 5 ml of sterile water
Gently mix until completely dissolved
Check solution clarity
02

Dosage Calculation

Calculate precise dose based on weight and animal species

Weigh the animal
Apply species coefficient
Calculate volume in ml
03

Drug Administration

Intravenous and/or intramuscular injection with aseptic technique

Disinfect injection site
Inject slowly into muscle
Monitor animal condition
04

Monitoring

Observe animal throughout the duration of action

Monitor breathing and pulse
Control body temperature
Record recovery time

Action Timeline

0-2 min
Drug administration
2-5 min
Sedation onset
5-10 min
Full anesthesia
30-90 min
Duration of action
90-120 min
Recovery

Important Notes

  • • Administer only after thorough clinical examination of the animal
  • • Ensure continuous monitoring of breathing and cardiac activity
  • • Have equipment for artificial ventilation available
  • • Store prepared solution for no more than 10 days at 2°C to 8°C
  • • Do not use in animals with liver or kidney disease

Safety Information

Important information about contraindications, side effects, and precautions

Contraindications

Cardiovascular diseases

Severe rhythm and conduction disorders

High risk

Neurological disorders

Epilepsy, traumatic brain injuries

High risk

Febrile conditions

Body temperature above 40°C

Moderate risk

Elevated intraocular pressure

Glaucoma and other ophthalmic conditions

Moderate risk

Possible Side Effects

Apnea (brief)

Frequency: 5-10%Moderate

Hypothermia

Frequency: 15-20%Low

Hypersalivation

Frequency: 25-30%Low

Muscle rigidity

Frequency: 10-15%Moderate

Tachycardia

Frequency: 20-25%Low

Vomiting on awakening

Frequency: 5-15%Low

Antidotes and Emergency Measures

Flumazenil

Zolazepam antagonist

Dose: 0.01-0.02 mg/kg

Atipamezole

For rapid awakening if needed

Dose: 0.05-0.1 mg/kg

Oxygen therapy

For respiratory depression

Dose: As needed

Emergency Protocol

For respiratory depression:
  • • Ensure airway patency
  • • Start oxygen therapy
  • • Provide mechanical ventilation if needed
  • • Administer antagonist
For cardiac insufficiency:
  • • ECG monitoring
  • • Hemodynamic correction
  • • Infusion therapy
  • • Cardiotonic drugs

About the Manufacturer

VETSTEM LLC - a leading Russian manufacturer of veterinary drugs

VETSTEM LLC

Veterinary Pharmaceuticals

We specialize in developing and manufacturing innovative veterinary drugs and cellular regenerative therapy.

Our mission is to provide veterinarians with reliable, safe, and effective tools for animal health care.

Contact Information

Legal Address:

121205, Moscow, Skolkovo Innovation Center,

Bolshoy Boulevard, 42, bld.1, office 209

Phone:

+7 (917) 525-77-70

+7 (495) 768-08-49

Registration Certificate:

No. 77-3-29.23-5075ПВР-3-29.23/03889

dated 12.04.2024

5+
years in market
85%
market coverage

GMP Certificate

International quality standards

Top Specialists

In veterinary pharmacology

Wide Recognition

Over 85% of Russian clinics

Skolkovo Resident

Advanced technology and innovation

Less than 0.03%

Adverse reaction reports

R&D and Manufacturing in Russia

Guaranteed quality and technical support

Development History

2020 Company Founded
Establishment of VETSTEM LLC with focus on innovative veterinary solutions
2022 Skolkovo Resident
Granted resident status at Skolkovo Innovation Center
2022 FIP Drug Development
Development of drugs for feline infectious peritonitis treatment
2023 Anesthetic Line Development
Development of drugs for safe and effective animal anesthesia
2024 VEZOTIL Launch
Successful registration of innovative animal anesthesia drug

Quality Certificates

GMP

Good Manufacturing Practice

ISO 9001

Quality Management System

Rosselkhoznadzor

State Registration

Contact & Order

Contact us to order VEZOTIL or get a consultation

Contact Information

Phone

+7 (917) 525-77-70

+7 (495) 768-08-49

Hotline and consultations

Email

vezotil@vetstem.ru

info@vetstem.ru

Product and general inquiries

Manufacturer

VETSTEM LLC

Russian company

Business Hours

Mon-Fri: 9:00-18:00

Consultations and orders

Reliable and Fast Delivery

VEZOTIL 250mg + 250mg, 5 mlPrice on request
Minimum order:35 packages
Delivery time:3-5 business days

Submit Request

Additional Information

Payment

Bank transfer for legal entities

Delivery

Worldwide shipping via courier services

Documentation

Complete veterinary documentation package

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